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| Tumor Type | Myc Gene Type | Cause of Myc de-reg1 | No. of Cases | % with Myc Dereg. | Incr. Myc2 R P | Clin./Path correl. (+/-) | Molec. Correl. (+/-) | Reference(s) | Tumor Type | | Colon |
c-myc |
Amp, Overexp |
33 -Ca, 36 Ad Pol9 |
61, 64 |
RNA |
2/12 tumors w/ modest, amplific., c-Myc. |
Frequent overexpr of N-myc and L-myc seen in Cas |
2668847 |
Colon |
| Gastric |
c-myc |
Amp |
16 |
19 |
RNA |
- |
- |
2579323 |
Gastric |
| Gastric |
c-myc |
Amp |
23 |
26 |
- |
+mets |
- |
9408311 |
Gastric |
| Gastric |
c-myc |
Overexp |
76 |
47 |
Prot |
+prolif., -diff, -survival |
- |
10576148 |
Gastric |
| Gastric |
c-myc |
Amp |
154 |
16 |
- |
- |
Amplif. of c-erb2 and/or c-met |
9759658 |
Gastric |
| Gastric |
c-myc |
Overexp |
35-adv, 74-early |
34, 16 |
Prot |
+ prolif. |
Prot |
12167117 |
Gastric |
| Gastric |
c-myc |
Overexp |
12 high, gr. dysplas, 98 late ca, 45 early ca, 16 low gr. dysplas |
-, 17, 28, 34, 40 |
Prot |
- |
-p53 (rare) |
10809364 |
Gastric |
| Gastric |
c-myc |
Amp |
21 |
48 |
- |
- |
- |
9369962 |
Gastric |
| Gastric |
c-myc |
Amp |
10 |
30 |
- |
- |
-p53 |
10704677 |
Gastric |
| Hepatoca |
c-myc |
Amp |
20 |
50 |
- |
+grade, -survival |
- |
8657726 |
Hepatoca |
| Hepatoca |
c-myc |
Overexp |
25 |
100 |
Prot, RNA |
- |
All samples also showed incr. expr. Of ODC mRNA and protein |
7687263 |
Hepatoca |
| Hepatoca |
c-myc |
Amp |
42 |
33 |
- |
+size, -age, -DFS, -diff |
- |
10461064 |
Hepatoca |
| Hepatoca |
c-myc |
Overexp |
40 |
48 |
Prot |
- |
- |
8104947 |
Hepatoca |
| melanoma |
- |
- |
- |
- |
- |
-survival |
- |
- |
melanoma |
| Melanoma |
c-myc |
Overexp |
40 |
48 |
Prot |
- |
- |
11237497 |
Melanoma |
| Melanoma |
c-myc |
Overexp |
60 |
43 |
Prot |
+adv. dis., +prolif. |
- |
7633656 |
Melanoma |
| Melanoma |
c-myc |
Overexp |
12-nevi, 7-margins, 33 –adv, 8 -primary |
33 |
Prot, RNA |
+adv. dis., +mets |
- |
11139316 |
Melanoma |
| Melanoma |
c-myc |
Overexp |
48 -mets |
96 |
Prot |
-survival |
- |
9422944 |
Melanoma |
| Melanoma |
c-myc |
Overexp |
94 |
96 |
Prot |
+mets, -class I HLA expression |
- |
8783648 |
Melanoma |
| Melanoma |
c-myc |
Overexp |
97 |
94 |
Prot |
-survival |
- |
11506326 |
Melanoma |
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There are 93 studies in this Myc database. Use the numbers below to page through the studies.
1 | 2 | 3 | 4 | 5 | |
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Last Updated: 04/14/03
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Funded by a grant from the National Library of Medicine
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